When the gene editing tool CRISPR-Cas9 rocketed to fame more than a decade ago, it transformed biotechnology. Faster, cheaper, and safer than previous methods, the tool helped scientists gain insight ...
A version of this Priestley Medal address will be presented at the American Chemical Society Spring 2026 meeting ...
At the heart of this technology is the Cas9 protein, often likened to molecular scissors, capable of cutting strands of DNA at specific locations dictated by a single guide RNA. With this mechanism, ...
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Scientists reveal functional RNA splitting mechanism behind origin of type V CRISPR systems
CRISPR-Cas systems are adaptive immune systems found in prokaryotes that defend against invading nucleic acids through CRISPR RNA-guided cleavage. Type V CRISPR-Cas (Cas12) systems, in particular, ...
Even without deep computational skills, scientists can use the CRISPRware program to quickly browse entire libraries of precomputed guide RNAs for six model organisms, zoom in on their gene or region ...
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