Moving Target: New Biology Casts TREM2 as a Shifty Mark
Apr 17, 2025 · Ever since the discovery of AD risk-stoking variants of TREM2, the microglial receptor has given scientists seeking to nail down its function a run for their money. It binds many ligands, …
Trialists Grapple with How to Outsmart TREM2 | ALZFORUM
Series - AD/PD™ 2025: Advances in Science & Therapy: Part 1 of 15: Finally, PET Tracers For α-Synuclein Yield Signal in Idiopathic Parkinson’s Part 2 of 15: New Partnership Forms to Harness AI …
TREM2: A Chill Pill for Neurons? | ALZFORUM
Apr 17, 2025 · TREM2 created quite the buzz at this year’s AD/PD meeting, held April 1-5 in Vienna. In the wake of a TREM2 agonist’s demise, scientists presented optimistic findings from early phase …
VG-3927 | ALZFORUM
Jun 6, 2025 · In September 2023, VG-3927 became the first small-molecule TREM-2 agonist cleared to enter the clinic. In October 2023, the first volunteer was treated in a Phase 1, placebo-controlled, …
All Roads Lead to TREM2: Gearing Up to Target This Receptor
Since the discovery of rare, yet potent risk variants in the TREM2 gene 11 years ago, the microglial receptor has emerged as a pivot point in the pathogenesis of Alzheimer’s disease. Findings …
Trem2 R47H KI x APOE4 (LOAD1) - ALZFORUM
Oct 4, 2023 · The epsilon-4 allele of Apolipoprotein E and the R47H variant of Trem2 have each been found to confer an approximately threefold increased risk for Alzheimer’s disease in humans …
TREM2-IPD | ALZFORUM
May 21, 2024 · Summary Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) is a transmembrane receptor found on microglia, where it modulates cell activity and survival. In addition …
Two Paths for TREM2-Positive Microglia: DAM or Senescence?
Apr 26, 2024 · Senescent microglia in amyloidosis mice express high levels of TREM2. They have distinct protein profiles from disease-associated microglia (DAM). The two TREM2 subtypes are hard …
Ferried Into Brain, TREM2 Antibody Stirs Microglia | ALZFORUM
Jan 23, 2023 · TREM2 antibody sports transferrin receptor binding domain to ease entry into brain. It activated microglia and boosted brain glucose metabolism. The antibody is in a first Phase 1 trial.
A tetravalent TREM2 agonistic antibody reduced amyloid ... - ALZFORUM
Sep 12, 2022 · Zhao P, Xu Y, Jiang L, Fan X, Li L, Li X, Arase H, Zhao Y, Cao W, Zheng H, Xu H, Tong Q, Zhang N, An Z. A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse …