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dna damage active tetramers cell cycle mdm2 p53 figure mdm2 and ps3 signaling in response to dna damage controls cell cyele progression the p53 and mdm2 proteins are involved in the dna dama 61699
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p53 is the guardian of the genome. p53 knockout mice (-/-) are highly susceptible to formation of tumors. why? failure to detect or accurately repair DNA damage can lead to oncogenesis, particularly if the mutations are in genes controlling the cell cycle, metabolism, and/or apoptosis #biochem #molecularbiology #oncogenesis #p53 #biotok #premed
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